Turn complex workflows into a streamlined process.
GRADEpro is an online software platform that helps teams of clinicians, methodologists, and policymakers develop and share evidence-based guidelines in a clear, structured, and transparent way.
GRADEPRO streamlines the entire process, from collecting Conflict of Interest Forms and analyzing research in Interactive Evidence Tables, to guiding panel discussions with the Evidence-to-Decision Framework and capturing input through PanelVoice.
Drafting is simplified with Collaborative Guideline Authoring, ensuring all team members and panel experts work from the same version.
Once recommendations are ready, GRADEpro makes dissemination easy: Guidelines can be exported to journals and professional publications, or published in digital formats using the Visual & Interactive Guideline module, Recommendation Maps, or the AI-powered RecChat assistant.
These tools ensure recommendations are not only developed with rigor but also delivered in ways that are accessible and useful to clinicians, policymakers, and patients.
With features like Offline Mode for uninterrupted work and a central Publication Platform for storing and searching guidelines, GRADEpro helps organizations reduce manual effort, maintain transparency, and maximize the reach and impact of their guidelines.
Features of GRADEpro
Tracking Conflict of Interest manually is time-consuming and error-prone, increasing the risk of poorly managed forms that undermine the credibility and trustworthiness of recommendations. Easily collect and update forms, send reminders, track responses, and manage conflicts in the voting process all within GRADEpro to ensure transparency and accountability.
Forming recommendations from complex research evidence can be difficult and result in inconsistencies, especially when multiple factors and perspectives are involved. The Evidence to Decision Framework was developed by the GRADE working group and helps by structuring panel discussions, guiding judgments step-by-step, and documenting decisions in a systematic way. GRADEpro has implemented this framework within the software to help your development process.
Summarizing research data into different and clear, standardized tables is time-consuming. GRADEpro's Interactive Evidence Tables, including Network Meta-Analysis, helps by automatically generating GRADE Evidence Profiles and Summary of Findings tables, integrating meta-analysis data, calculating certainty, and allowing export in multiple formats for easy sharing and review.
Coordinating input from different panel members can be slow and fragmented when relying on emails or scattered tools. PanelVoice provides a dedicated space for discussion, voting, and commenting, making decision-making more efficient and unified.
Sending multiple text files back and forth and tracking multiple versions of the guideline manuscript can be overwhelming and tedious. GRADEpro offers a centralised platform that guideline members can access in order to leave their comments or suggest changes to the content, as well as easily integrate recommendations made with other GRADEpro features.
Clinical guidelines are often complex, making it challenging for interest-holders to interpret and apply recommendations effectively. The Visual & Interactive Guidelines Module solves this by turning guidelines into a compact, digital, and interactive format, allowing users to explore outcomes, adjust comparators, incorporate cost data, and view narrative and data presentations"
It is time-consuming trying to find relevant, and reliable guideline information across multiple repositories. RecChat, GRADEpro's AI model, solves this by acting as a specialized search assistant, trained to query a single database of peer-reviewed guidelines, delivering precise, trustworthy answers without hallucinating or generating incorrect information.
Accessing and working on guideline projects can be disrupted by limited or unreliable internet connectivity or the need to travel. Offline Mode solves this by allowing the continuation of work without an internet connection, syncing changes automatically when reconnecting, so work can continue seamlessly anywhere.
Making guidelines easily accessible is no easy feat, especially if they are published across different journals, volumes and dates. The publication platform can be your dedicated repository of all guidelines, which can be easily accessed, searched and filtered, including AI assistants, so the users can find relevant information efficiently.
It may be hard for end users to find relevant information when recommendations are scattered across lengthy guidelines, with numerous versions and updates available, often presenting conflicting information. Recommendation Maps help organise recommendations across guidelines on a grid of interventions and populations, so that patients and healthcare providers can easily find recommendations of interest and compare different versions, while researchers are able to determine points of confusion or research priorities.
GRADEpro has been an invaluable tool for our Centre, supporting numerous Cochrane Reviews and, more recently, guideline development where Cochrane evidence informed WHO recommendations.
Working with Evidence Prime has transformed our clinical practice guideline development process. Their team is exceptionally responsive and creative, delivering flexible solutions that have unlocked new efficiencies and elevated the quality of our work.
GRADEpro has been an essential tool for our team at the RAY CRO, enabling us to develop high-quality, evidence-based recommendations with efficiency and accuracy.
GRADEpro is a helpful tool frequently utilized by the International Liaison Committee on Resuscitation (ILCOR) to support the development of Consensus on Science and Treatment Recommendations. GRADEpro is particularly helpful at supporting recommended GRADE workflows and facilitates collaboration amongst geographically diverse teams.
The Pakistan Blood and Marrow Transplant (PBMT) Group, has had a very rewarding experience using GRADEpro. The platform has provided a structured, evidence-based framework that makes guideline development more systematic and transparent. It has enabled our multidisciplinary teams to critically appraise the available evidence, balance benefits and risks, and develop recommendations that are both rigorous and practical for our local context.
GRADEpro webinars are a good way to learn the various tools available in GRADEpro. For example, I’ve used webinars to learn how to navigate the software to perform many tasks. This includes GRADE assessments to disseminate recommendations and for assistance in writing clinical practice guidelines by using the “Conclusions” outline provided after the type of recommendation table. This is a logical and useful tool for guidelines methodologists.
Our team has used GRADEpro to develop over 20 clinical practice guidelines in the field
of critical care medicine and related disciplines. We appreciate the many features of GRADEpro which have allowed us
to create transparent and trustworthy practice guidelines. It is absolutely central to our process of guideline creation.
GRADEpro is particularly helpful at supporting recommended GRADE workflows and facilitates collaboration amongst geographically diverse teams.
Collaborating with Evidence Prime has enabled IDSA to continue innovating how we develop and disseminate guidelines for infectious diseases. Their leadership in technology platforms and innovations in AI-powered tools for guideline development makes them a power partner for guideline developing organizations like ours.
